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Source: http://www.facebook.com/KOAT7/posts/119831891500275
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Sunday, September 30, 2012
Backpacking travel & Outdoor adventure: 2012 - Backpacking to ...
Backpacking to Perth WA
Cape to Cape of Margaret River Valley
07 Sept to 18 Sept 2012
Day 09 Sat. (15.09.2012) - Kings Park and Taste Bud Tours
We had a heavy morning breakfast and then drove along the Swan River towards Kings Park. This large city park consists mostly of native bush and is an escape from the city with popular picnic areas and bike paths. There are good views of the city centre from the higher points in the park.
We then walked along the main streets in Perth: Murray St, and Hay St. We walked through the London Court by the north entry and end up at Wellington St.
At 1:15pm pickup from the Wellington Tourist Coach Stand for the Taste Bud Tours, a 4.5-hour half day tour in a spacious air-conditioned coach along the famous Swan Valley Food & Wine Trail. Sample local wines, sweet and savory foods, beers, ciders and coffees. Currently ranked #1 Tour in Perth on Trip advisor. The Deal: $249 for a half-day ?Speed Grazing? experience for 6 in the Swan Valley ($710 value). Taste Bud Tours offers a unique ?speed grazing? experience to show you all the Swan Valley?s highlights in only half a day ? it?s fast, fun and filling. Voted Best New Business in the 2011 Small Business Awards.
The Highlights are visiting:
- Yahava Koffee Works
- Cape Lavender
- Mago Coffee
- Margaret River Chocolate Co.
- Jarrah Ridge Wines
- The House of Honey
- Mondo Nougat Factory
- Roadside Farmstall
- Ironbark Brewery
1st surprise: Pauline met her Sitiawan ACS school colleague son ? Mr. Chandra Boss and family.
2nd surprise: I met my former Public Bank colleague ? Ms. Koay Seok Khim.
Finished the tour at 6.30pm we took the train to Bull Creek where Dave waited to drive us back to Seah?s Haven. Again and again we had fantastic dinner and this time is the grill-out pork using the Weber charcoal grill at the backyard.
Sleeping: Seah?s Haven
Temperature: Sunny 24?C/12?C
click here to continue day 10, 11 and 12
Source: http://chingnengbin.blogspot.com/2012/09/2012-backpacking-to-perth-day-9_30.html
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Smoking Cigarettes
Hooked! ? There would be no better way to describe my years of dependence on cigarettes. I had to have a cigarette. That is the way it was for me once upon a time. Smoking cigarettes is one of greatest mistakes I ever made.
It was the cool thing to do. Nobody I knew knew it was a deadly habit. People smoked around babies, in restaurants, in movie theaters, and even on public transportation. You smoked wherever you wanted. It seemed everybody smoked.
There was no such thing as second-hand smoke. It was unheard of. In the 1960?s people spent many hours in smoke filled rooms, whether they were smokers or not. If you were a smoker you would walk a country mile if you ran out of cigarettes and had no other way to get to a store. You were hooked.
Cigarette smokers will spend their last penny or beg for extra change if they run out of cigarettes. They will do just about anything to support their habit. Quitting is no simple matter, either. It could very well be one of the hardest things you do in your life. But it can be done.
I tried to quit for years. I just couldn?t do it, at the time, and continued to puff my life away. One day fate stepped in when an old friend I hadn?t heard from in years called. ?Just wanted to see how you were doing,? he said. The last time I saw him he was a 2-pack a day smoker.
?Guess what, I quit smoking, he continued ... been 4 years.? He said he was amazed that he had actually succeeded and that he had used sunflower seeds to do it. I thought that over for about a week before I went out and bought a nice big bag of sunflower seeds in the shells.
My friend explained that you have to get the sunflower seeds in the shell, not the shelled kind. You need the shells for the cracking and splitting activity ? it is something to do with your hands and your mouth. Cigarette smoking is an oral fixation. It supplies continuous hand-mouth activity.
The sunflower seeds substitute the hand-mouth activity through the hard parts of withdrawal. They replace the cigarettes and offer you a substitute while you are detoxing. Hand to mouth, hand to mouth, something in your hand to put in your mouth. Just like cigarettes.
Instead of sucking up the smoke and blowing it out, you chew open shells and spit them out. Much healthier! I haven?t had a cigarette in over a decade. The sunflower seeds did the trick for me, too. Remember the cigarette smokes you?re just the sucker. Good luck!
Source: http://www.streetarticles.com/pure-opinion/smoking-cigarettes
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Hoffenheim player Boris Vukcevic still critical
Associated Press Sports
updated 7:13 a.m. ET Sept. 29, 2012
HOFFENHEIM, Germany (AP) -Hoffenheim midfielder Boris Vukcevic remains in critical condition following Friday's traffic accident in which his car collided head on with a truck.
Hoffenheim spokesman Holger Tromp says that "it's not possible to give an outlook at this time."
Vukcevic is in an induced coma in a Heidelberg hospital after receiving life-threatening head injuries. The collision occurred on Friday afternoon between Hoffenheim and Heidelberg in southwestern Germany.
Vukcevic was airlifted to the hospital where the coma was induced after an operation. The truck driver received treatment for minor injuries.
Hoffenheim's Bundesliga game against Augsburg was to go ahead Saturday.
Hoffenheim general manager Andreas Mueller says the players "want to fight for him, because we know that's what he would have wanted."
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsAFP - Getty ImagesSource: http://nbcsports.msnbc.com/id/49212541/ns/sports-soccer/
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Tablet Locked down for China
Today, 05:35 AM
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Tablet Locked down for China
Hi,
I bought this tablet on-line locally while in China on business last week. Overall really pleased with it but some problems which make me think it might be locked down for use in China. Tempted to install a vanilla version of Ice Cream Sandwich over the top but surely that's too easy (and I don't know how to do it!) ? Please can anyone help?
Device:
Onda V712 Dual Core Dual Camera 7 inch 1280*800 IPS HD Touch Screen HDMI WIFI 16GB
Problems:
Can't access Facebook online (error 404) or via Android App (login doesn't reach facebook servers). Other sites giving 404 are Youtube and Google.
Can't download from Google Play Store (-101 on commencing download), have to use a Chinese equivalent (AnZhi) which takes ages to download apps which take seconds on my Samsung Galaxy Ace mobile and doesn't have some UK apps like the new BBC Media player for using the iPlayer.
?
|
Last edited by ScottF; Today at 05:37 AM. |
Source: http://androidforums.com/android-lounge/625226-tablet-locked-down-china.html
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How do i trade my battle pets ?
Originally Posted by Demiano 
right click the pet in your list and choose "put in cage" if the option is available, sometimes they need to be healed before you can put in a cage. Then it will be in you inventory and you can do what you want, trade or auction.
Source: http://www.mmo-champion.com/threads/1203943-How-do-i-trade-my-battle-pets
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Saturday, September 29, 2012
John Vespasian: Consistency is the key to clear thinking. How to ...
Consistency is the key to clear thinking. Aristotle described the principles of logical reasoning already in the year 345 B.C. Twenty four centuries later, his conclusions remain applicable. Entities should be defined on the basis of their essential characteristics. Actions lead to consequences. Today's events are the result of previous occurrences. Those few principles govern reality.
How to formulate your long-term objectives
How to formulate your long-term objectives
When a man formulates his long-term objectives, he should strive to write them clearly and break them down into simple steps. A comprehensive philosophy that cannot be summarized into a few sentences is of little practical use.
Ambitious goals require sustained effort, often over a period of decades. Reducing complex strategies to simple formulas motivates us to attain intermediate targets. Happiness is the result of preceding actions that generate slow incremental progress. Sharp thinkers look, at the same time, far into the future and close into the present.
You cannot escape the requirement of clarity
There is no way of escaping the requirement of clarity. Talking about forthcoming achievements becomes irrelevant if we are unable to define what we need to do today. The feasibility of long-term ambitions depends on man's ability to reduce them to sequential steps.
Mistakes arise from the temptation to move too fast towards our objectives. Disorganized ventures fall prey to their own chaos. Without a well-designed plan, self-reliance turns into doubt and convictions into prejudice. Without a method to filter out irrelevancies, man gets lost in secondary roads that lead him away from his goals.
Unclear expectations undermine reason
Lack of thoughtfulness leads to exaggerate problems and blow inconveniences out of proportion. Unclear expectations undermine reason. Confusion renders tasks heavier than they have to be. Contradictory values bring about unbridled emotions. Inconsistent criteria waste energy in endless discussions and destroys the ability to perform well.
In the kitchen, only detailed recipes give consistent results. Eating well is the overall objective, but actual cooking relies on specific ingredients, temperature, seasoning, and a formula that combines them. Failing to identify concrete elements of action makes impossible to implement plans and deprives man of confidence on his own abilities.
Imprecise plans and performance criteria blind our eyes. Today's random actions destroy yesterday's creations. Self-inflicted contradictions lead to failure, anger, and anxiety. A company whose employees render erratic, unpredictable services is doomed. Never trust individuals who are long on philosophical talk and short on implementation details.
Condense your strategy into a simple formula
Quality controls are useless if people don't know what they are doing. Quality requires clear objectives, purposeful thinking, and continuous action. If you want to be taken seriously, break down your twenty-year goals into monthly steps. The workable approach to happiness is a rational connection between our present actions and our life objectives.
Manufacturers follow a production formula to ensure that they are using the right materials. Check-lists permit managers to assess if a worker is sufficiently trained to do his job. A company's compensation plan aligns the interests of employees with the corporate goals.
Nobody can figure out all right answers all the time, but if you condense your strategy into a formula, mistakes will be self-correcting. Chaos leads to more chaos, but a recipe can be improved from experience. Breaking down long-term goals into detailed steps is of critical importance in business and private life.
For more information about rational living and personal growth, I refer you to my book about how to be rational? "The 10 Principles of Rational Living"
[Text: http://johnvespasian.blogspot.com]
[Image by EDD07 under Creative Commons Attribution License. See the license terms under http://creativecommons.org/licenses/by/3.0/us]
Source: http://johnvespasian.blogspot.com/2012/09/consistency-is-key-to-clear-thinking.html
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A glance at Spanish banks that failed stress test
MADRID (AP) ? The Spanish government announced Friday the result of financial health-checks on its 14 main credit institutions. Seven of them, representing 38 percent of the country's banking system's credit portfolio, failed the so-called stress tests and need to pad their capital cushion to cope with economic adversity.
The government said the total capital needs of those seven banks amount to ?59.3 billion ($76.3 billion).
This is a list of the banks which failed the test and the amount of extra capital they need to make them safe, according to the test's yardsticks. The first four banks listed have been nationalized to prevent them collapsing.
? Bankia-BFA: ?24.7 billion ($31.9 billion)
? Catalunyabank: ?10.8 billion ($14 billion)
? NovaGalicia Banco: ?7.2 billion ($9.3 billion)
? Banco de Valencia: ?3.5 billion ($4.5 billion)
? Popular: ?3.2 billion ($4.1 billion)
? BMN: ?2.2 billion ($2.8 billion)
? Ibercaja-Caja3-Liberbank: ?2.1 billion ($2.7 billion)
Source: http://news.yahoo.com/glance-spanish-banks-failed-stress-test-172634259--finance.html
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10 Things to Know for Friday
Your daily look at late-breaking news, upcoming events and the stories that will be talked about Friday:
1. CLINTON, NETANYAHU DISAGREE ON IRAN STRATEGY
The U.S. secretary of state hopes diplomacy can avoid the military action the Israeli leader urges.
2. FOR ONCE, IT'S HAIL TO THE REFS
A cheering crowd welcomes back NFL's men in black and white for the Browns-Ravens game in Baltimore.
3. CANDIDATES BEWARE: THE DEBATES CAN DEFINE YOU
Obama and Romney face off Wednesday, aware of what tripped up Nixon, Gore and the first President Bush.
4. PRODUCER OF ANTI-ISLAMIC VIDEO ARRESTED ON PROBATION VIOLATION
Nakoula Basseley Nakoula was barred from using computers or the Internet for five years without approval.
5. VATICAN SCHOLARS INSIST JESUS WASN'T MARRIED
The Holy See's newspaper says a Coptic papyrus fragment referring to a wife is fake.
6. WHY POLICE ARE SKEPTICAL ABOUT THE LATEST HOFFA SEARCH
The Detroit probe follows decades of unfounded reports that the Teamster boss's body was entombed under Giants Stadium, discarded in a Florida swamp or buried at several Motor City locations.
7. MARS ROVER FINDS SIGNS OF AN ANCIENT STREAM
The discovery confirms that the dry and dusty red planet was once warmer and wetter.
8. VICTIMS MAY BE ABLE TO VISIT SITE OF COLORADO SHOOTING
Some want to go back to the movie house as part of the healing process.
9. LADY LIBERTY MAY HAVE A TALLER NEIGHBOR BY 2015
New York Mayor Michael Bloomberg unveils plans to build the world's tallest Ferris wheel on Staten Island.
10. THE DESPAIR OVER 'SONS OF ANARCHY' ACTOR'S FINAL ACTS
The show's creator says Johnny Lewis, found dead in Los Angeles, "had lost his way" when he took the life of the landlady "thrown into his destructive path."
Source: http://news.yahoo.com/10-things-know-friday-103047600.html
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In Iran, sanctions bite and currency collapses
Raheb Homavandi / Reuters file
A money changer holds Iranian rial banknotes as he waits for customers in Tehran's business district in this January 7, 2012 file photo.
By Ali Arouzi, NBC News correspondent
TEHRAN ? Even though threats of war with Israel are almost a daily occurrence, what?s really on people's minds in this city is the economy.
The United States, the European Union and the U.N. have imposed tough economic sanctions against Iran, blocking access to the international banking system and curbing sales of Iranian crude oil as a way to persuade Tehran to abandon its nuclear program.
As a result, Iran?s currency, the rial, is in a constant state of flux, but mostly on a downward trajectory. These days, it seems to fall in value against the dollar on an hourly basis. On Tuesday the currency hit an all-time low against the U.S. dollar, trading at 26,500 to the U.S. dollar on the open market, according to Persian-language currency tracking website Mazanex.?
?Our money is becoming more and more worthless every day,? said Sarvenas Sadi, an elderly woman doing her daily shopping in Tehran earlier this week.
She picked up a handful of limes and exclaimed, ?These were 100 percent cheaper last year!?
Asked whether she ever thought she would see the currency devalue so much, she replied, ?Never! I remember before the [1979] revolution $1 was worth 70 rial, now it?s worth 26,000! Who would have ever have thought!?
Iranians feel the pain of sanctions: 'Everything has doubled in price'
Did she think things would ever balance out and the price of goods would come down to what they were before. ?Unfortunately I don?t think so. The thing with Iran is that once the price of something goes up, it never comes down again.?
So what?s the solution?? ?Eat less limes,? she jokingly replied.?
AP
Two potential Iranian customers look at fabric bolts in Tehran's old main bazaar in this picture taken July 14, 2012.
Manufacturing hit hard
The financial situation is affecting people from all classes. Thousands of workers have been laid off and have not been paid back wages because companies have simply run out of money. Majid, a 32-year-old mechanic who used to work for a large car company was recently laid off and is owed six months? salary.
?They are laying off people left, right and center. I doubt there will be a company left by the New Year,? he said, giving just his first name because of the sensitivity of the issue in Iran. Persian New Year will be on March 21, 2013.
The car industry, one of the biggest manufacturing sectors in Iran and a massive employer, has been affected dramatically; Iranian media have reported a 30 to 50 percent drop in car and component production in the past six months. Iran was the 13th-largest auto maker in the world in 2011, producing 1.6 million vehicles.
The Iran Khodro Company, the country?s leading vehicle manufacturer, had become the largest vehicle manufacturer in the Middle East,?Central Asia?and North Africa. ?The company won the annual national prize for export activities in 2006 and 2007 with Russia, Syria, Turkey, Iraq, Azerbaijan, Ukraine, Egypt, Algeria and Bulgaria among their key consumers.
But higher prices, due to the soaring costs of components as a result of the sanctions, have caused a drop in demand.
Israel's Netanyahu: Draw 'clear red line' to stop Iran from getting nuclear weapons
For instance, France's Peugeot Citroen halted shipments of vehicle kits for assembly in Iran earlier this year, saying international sanctions barring transactions with the country's banking system made it difficult to obtain sales financing.
Sanctions have taken a toll on the Iranian economy. The government is reluctant to admit it. Inflation is high. The number of young unemployed is a growing concern. NBC's Ali Arouzi reports.?
Majid, the mechanic, said he is looking for work elsewhere but it is proving very difficult. ?There are not many jobs going and it is getting me more and more depressed.?
Oil sales to travel - down
The oil sector has been hit hard too.? The Iranian Labor News Agency reported that a letter on behalf of 20,000 oil workers from across the country was sent to Labor Minister Abdolreza Sheikholeslami complaining that they had not been paid in months. The letter demanded an increase to the worker?s salaries of $120 to $285 a month, adding that at the current rate they were "way below the poverty line.??
Mohammad Reza Bahonar, a prominent Iranian member of parliament, said oil exports in June-July had dropped to "around 800,000 barrels per day," according to a report by ISNA news agency. That?s a low not seen in more than two decades, and less than half the 2.3 million barrels per day exported just a year ago.
But Minister of Petroleum Rostam Qasemi was quoted by ISNA saying that overall oil production this year "will be the same as last year."
Israel's Prime Minister Benjamin Netanyahu called for a firm deadline for Iran to halt its nuclear program, using a simple drawing to warn the UN that Iran will soon reach the point of no return in its development of nuclear weapons. NBC's Andrea Mitchell reports.
The strangling of the economy isn?t just affecting blue-collar workers.
Middle-class Iranians had become accustomed to foreign travel ? to Dubai, a playground for Iranians only an hour and half away, Turkey, one of only a few countries that does not require visa?s for Iranians, and Thailand. But the cost of travel to any of these destinations is prohibitive to many.
More Iran coverage from NBC News
Maryam, a travel agent in Tehran who also only gave her first name, estimated that the number of travelers has been halved in a year. ?The price of tickets and organized tours increased almost a hundred fold. They say that this will boost domestic holidays, but I think that is even too expensive for most people.?
This was evident to me last month flying back to Tehran from London via Dubai. Usually the flight from Dubai to Tehran is jammed, but not this time. Business and first class were full with the super-rich of Iran, but 70 percent of the plane which makes up the economy class was almost empty.
As the American mission in Afghanistan winds down, dangers still abound for U.S. troops ? the most recent incident involved a Taliban gunman who fired on a U.S. Marine outpost in Afghanistan's Helmand Province. NBC's Richard Engel reports.
Expected to get worse
Mehdi is a young entrepreneur who imports computers and accessories who also spoke on the condition of anonymity. He said people are just not buying in Iran right now. His biggest wish was that the value of the rial would just stay fixed against dollar ? even if it was at an unfavorable rate ? just so consumers would know how much things would cost in a weeks? time, a day or even in the next few hours.
While the sanctions have certainly taken a major bite out of the economy and are hurting people from all walks of life ? it does not seem to be making the government authorities buckle. If anything it seems to have stiffened the government?s resolve and things are set to become even more difficult in the not too distant future. ?
Britain, France and Germany are urging their European Union partners "to further step up the pressure" on Iran. Further sanctions targeting the Islamic Republic's energy, finance, trade and transportation sectors are expected to be formally adopted on Oct. 15.
At schools, in shops, and on the streets of big cities and small towns, daily life plays out in Iran.
More world stories from NBC News:
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Google optimizes Flight Search for tablets, makes booking trips easier
It feels like it was only yesterday that we were praising Google for giving us access to a plethora of handy, everyday tools -- oh wait, it was yesterday. At any rate, today the folks from Mountain View are back with more travel-friendly software for you to enjoy, announcing that its useful Flight Search service is now fully-optimized for use with, as Google points out, tablets such as its own Nexus 7 and, naturally, Cupertino's iPad. Jet-setters can see the changes now by simply hitting the Flights link below, and with the dearest holidays just around the corner, now is probably a good time to make use of that "lowest fare" tool.
Filed under: Tablets, Transportation, Software, Google
Google optimizes Flight Search for tablets, makes booking trips easier originally appeared on Engadget on Fri, 28 Sep 2012 17:34:00 EDT. Please see our terms for use of feeds.
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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/4qw5hn10zis/
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Friday, September 28, 2012
Multiple similarities discovered between cancer cells and induced pluripotent stem cells
ScienceDaily (Sep. 28, 2012) ? UC Davis investigators have found new evidence that a promising type of stem cell now being considered for a variety of disease therapies is very similar to the type of cells that give rise to cancer. The findings suggest that although the cells -- known as induced pluripotent stem cells (iPSCs) -- show substantial promise as a source of replacement cells and tissues to treat injuries, disease and chronic conditions, scientists and physicians must move cautiously with any clinical use because iPSCs could also cause malignant cancer.
The article, "Induced pluripotency and oncogenic transformation are related processes," is now online in the journal, Stem Cells and Development.
"This is the first study that describes the specific molecular pathways that iPSCs and cancer cells share from a direct comparison" said Paul Knoepfler, associate professor of cell biology and human anatomy, and principal investigator of the study. "It means that much more study is required before iPSCs can be used clinically. However, our study adds to a growing knowledge base that not only will help make stem cell therapies safer, but also provide us with new understandings about the cancer-causing process and more effective ways to fight the disease."
Since 2007, cell biologists have been able to induce specialized, differentiated cells (such as those obtained from the skin or muscle of a human adult) to become iPSCs. Like embryonic stem cells, iPSCs are a type of stem cell that is able to become any cell type. This "pluripotent" capability means that iPSCs have the potential of being used in treatments for a variety of human diseases, a fundamentally new type of clinical care known as regenerative medicine.
iPSCs are considered particularly important because their production avoids the controversy that surrounds embryonic stem cells. In addition, iPSCs can be taken from a patient's own skin and induced to produce other needed tissues, thereby evading the possibility of immunologic rejection that arises when transplanting cells from a donor to a recipient. In contrast to therapies based on ES cells, iPSCs would eliminate the need for patients to take immunosuppressive drugs.
Earlier research indicated that both ES cells and iPSCs pose some health risks. Increasing evidence suggests that pluripotency may be related to rapid cellular growth, a characteristic of cancer. iPSCs, as well as embryonic stem cells, are well known by scientists to have the propensity to cause teratomas, an unusual type of benign tumor that consists of many different cell types. The new UC Davis study demonstrates for the first time that iPSCs -- as well as ES cells -- share significant similarities to malignant cancer cells.
The investigators compared iPSCs to a form of malignant cancer known as oncogenic foci that are also produced in laboratories; these cell types are used by medical researchers to create models of cancer, particularly sarcoma. Specifically, the scientists contrasted the different cells' transcriptomes, composed of the RNA molecules or "transcripts." Unlike DNA analysis, which reflects a cell's entire genetic code whether or not the genes are active, transcriptomes reflect only the genes that are actively expressed at a given time and therefore provide a picture of actual cellular activity.
From this transcriptome analysis, the investigators found that the iPSCs and malignant sarcoma cancer cells are unexpectedly similar in several respects. Genes that were not expressed in iPSCs were also not expressed in the cancer-generating cells, including many that have properties that guide a cell to normally differentiate in certain directions. Both cell types also exhibited evidence of similar metabolic activities, another indication that they are related cell types.
"We were surprised how similar iPSCS were to cancer-generating cells," said Knoepfler. "Our findings indicate that the search for therapeutic applications of iPSCs must proceed with considerable caution if we are to do our best to promote patient safety."
Knoepfler noted, for example, that future experimental therapies using iPSCs for human transplants would most often not involve implanting iPSCs directly into a patient. Instead, iPSCs would be used to create differentiated cells -- or tissues -- in the laboratory, which could then be transplanted into a patient. This approach avoids implanting the actual undifferentiated iPSCS, and reduces the risk of tumor development as a side effect. However, Knoepfler noted that even trace amounts of residual iPSCs could cause cancer in patients, a possibility supported by his team's latest research.
Encouragingly, the UC Davis team also found important differences between the cell types that could provide clues to making iPSCs safer. As part of this study, the researchers transformed tumor-generating cell types into iPS-like cells by manipulating their genetic make up. Although the reprogrammed cancer cells did not behave identically to iPSCs, and had reduced ability to produce different cell types, the findings are exciting because they suggest that cancer cells can be reprogrammed into more normal cell types, possibly opening the door to new cancer therapies.
"We found that we could reprogram the cancer cells to behave more akin to normal stem cells," said Knoepfler. "This suggests that such cancer cell reprogramming could become a new way of treating cancer patients, in essence telling their tumors to turn into normal stem cells."
Knoepfler said the team is continuing to study the differences and similarities between iPSCs and cancer cells, as well as investigate possible ways to make iPSCs safer. It appears that targeting specific metabolic pathways may enhance iPSC formation, while modulating other pathways may improve safety.
Other study authors are John Riggs, Bonnie Barrilleaux, Natalia Varlakhanova, Kelly Bush and Vanessa Chan, all of the UC Davis Department of Cell Biology and Human Anatomy.
The study was funded by grants from the California Institute for Regenerative Medicine and from the National Institutes of Health (NIH grant 5R01GM100782-01).
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The above story is reprinted from materials provided by University of California - Davis Health System.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- John W Riggs, Bonnie Barrilleaux, Natalia Varlakhanova, Kelly Bush, Vanessa Chan, Paul Knoepfler. Induced pluripotency and oncogenic transformation are related processes. Stem Cells and Development, 2012; : 120921101948002 DOI: 10.1089/scd.2012.0375
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/cxC7BCZc-5g/120928141100.htm
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Anybody here have a Samsung Galaxy S III cellphone (mobile for ...
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Is Lack of Communication a Red Flag? | World of Psychology
Over time I?ve learned to confront the infamous ?red flags? when it comes to the dating world.
There may have been a tiny voice inside my head that said ?this doesn?t seem right,? but because I didn?t truly want to believe that was the case, I?d push it aside and move on. Well, one of the more pet-peevish warning signs that always left me clueless was when the other person (in my situations it was a guy, but I don?t want to target the whole male species here) could not express how he felt.
It?s also unfortunate when the silence goes beyond just articulating feelings, and he simply can?t communicate? at all. Your messages and texts go ignored, and you?re left wondering how you didn?t foresee this issue to begin with.
We all know communication in relationships is important, but in the early stages, is a tight-lipped manner a red flag signaling you to run the other way?
I?d say yes, considering a block in communication is fatal in serious, long-term relationships. ?The degree of block can vary with the severity or repeating of the communication stop,? Daniel Evans writes in his article, ?The Importance of Communication in Relationships.? ?A block in the relationship exists or will grow when communication is just flat out avoided.?
Evans grew up with the notion of not wanting to upset others; however, that only propelled him to avoid communicating on touchy topics altogether. ?In adult relationships, this behavior only avoided the hard issues that people have to work through for the relationship to be healthy and grow.?
Along with avoidance, diversion is another troublesome communication tactic. If the other person?s questions and curiosities are not addressed, the relationship will no longer be able to move forward.
Anna Solo, a freelance photojournalist, asserts that a lack of communication in any stage of a relationship should be constituted as a red flag. ?People often wait to expose their flaws until after they?ve gotten comfortable with someone, so if that quality pops up right at the start, I feel like it can only go downhill from there,? she says. ?There?s a difference between being shy and being a bad communicator, and if someone can?t communicate well or can?t push themselves to from the beginning, what other foundation can there be for a good relationship? There?s no way to cultivate a healthy relationship if you can?t discuss things.?
Ashley Knox, who has a master?s degree in social work, wasn?t as quick to throw in the towel. She believes that communicating effectively may take time. ?You have to learn about the other person?s communication style and how it works with your own or how it conflicts with your own,? she notes. ?As a couple, all of that needs to be discussed. If communication cannot be improved, then there is no relationship to begin with. Being a couple means being a team and working on things together and growing together. Not every couple that gets together is going to have the same communication pattern. Everyone is raised differently and deals with problems differently.?
Freelance writer Shaheen Darr previously wrote about red flags in relationships. Darr believes that a lack of communication definitely needs to be taken care of before moving on. ?A partner who is withdrawn and not willing to show any love, either through communication or in a physical sense, will leave the other partner feeling unfulfilled and insecure.? Insecurity in itself definitely is not beneficial to relationships either.
Whatever the circumstances causing insufficient communication, when you start to feel that uncomfortable inkling that the dynamic is off, it probably doesn?t hurt to follow your intuition.
????Last reviewed: By John M. Grohol, Psy.D. on 26 Sep 2012
????Published on PsychCentral.com. All rights reserved.
APA Reference
Suval, L. (2012). Is Lack of Communication a Red Flag?. Psych Central. Retrieved on September 27, 2012, from http://psychcentral.com/blog/archives/2012/09/26/is-lack-of-communication-a-red-flag/
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Source: http://psychcentral.com/blog/archives/2012/09/26/is-lack-of-communication-a-red-flag/
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So happy
It's up to the chosen heros to rise up against the king of Thalrim. Strong story, Role Players create a lot of it. (Need Male and Female Heros, or neutral characters. Villains are covered!)
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This topic is an Out Of Character part of the roleplay, ?The Chosen, Revolution.?. Anything posted here will also show up there.Topic Tags:
Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.Alright guys, so I've done tons of Role plays online and stuff, and always get stuck with kids who don;t know how to type, and can't develop a character.
You guys are great, and every time I read a post, it excites me.
I have some awesome plans for this story, and you guys are making this my favorite RP... And we're just getting started xD
I like it so much, I made a new topic just to tell you guys...
Have my babies.
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typo1212 - Member for 0 years
LOL HIlarious, the only reason this is rpg is going so well is that your plots are really good as well as the villians
~The future is uncertain~
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JxLucky - Member for 0 years
Lol, I'm glad to hear that xD I'm excited for what I have in store for you guys. But I want to draw it out as much as possible, so we don't just jump into a war and start killing each-other. lol.
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typo1212 - Member for 0 years
LOL wow... so enthusiastic xD
The Sykes story is really intense, especially with the crystal thing going on,
I was just freaking out about how awesome it was ^^
I can't wait til all the Chosen Ones join together- I was worried that the meeting between Ericka and Tsubasa was going too quickly.
After I made my character, I realized we were set in Medieval Europe times and I was regretting my name choice so much xD
But its okay, I fixed it somehow lmao.
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ayuta - Member for 0 years
Lol, yeah, It's gonna be cool. Depending on how Tsubasa and Ericka's confrontation goes, things could get pretty epic, quickly. And it's going at a good pace, The first heroes have to meet eventually, and why not get it over with, so it's not just a bunch of people wandering around Europe? That's my biggest fear for this Role Play... To have it end up... with us... just walking.... around Europe.... and Me not knowing how to fix it xD
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typo1212 - Member for 0 years
Well, i believe Tsubasa was gonna go to Florence to meet Genevieve and bring her back, so our meeting is just by chance for now well on the other hand i will be staying in Rome and is now trying to think of a way to meet up with Sykes and maybe even Rolof
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JxLucky - Member for 0 years
Yeah, I'm thinking of some close encounters with Rolof, but I warned tigerking (plays Rolof), that Rolof is going to be disposable in the middle of the story. But he hunts the heroes, so he's bound to get burned. Either way, he's super strong int he beginning (I mean shit, He duel wields claymors, what a champ.)
Edit: Oh, and everything thus far has pretty much taken place in Rome, which is kind weird, considering that Sicily is totally close to Rome. So, the Heros will have to move away, if they don;t want to be totally wiped out by King Coal, who could easily kill them, if he knew they where there. Which Is why I always look at the map, and write at the same time, so I can think of good places to build a force, or hide from the King. Either way, Rome wasn't where I thought everyone would meet up, so either way the conversation goes is fine with me.
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typo1212 - Member for 0 years
I purposely placed myself in Rome cuz i thought the Holy Roman army would be there to protect us but it seems like that was hopeless
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JxLucky - Member for 0 years
*SPOILER* The roman army Will get crushed. *SPOILER SPOILER* I have a couple ideas, that's gonna make King Coal A real pain in the ass.
Edit: maybe crushed is a harsh term. But they will be beaten.
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typo1212 - Member for 0 years
that spoiler alert wasn't much of a warning xD
but i think we all saw that coming, that's why i was trying to get Tsubasa away from Rome (lol) didn't want to get stuck in the crossfire.
can't wait to see what other great ideas you have, keep 'em comin 8D
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ayuta - Member for 0 years
Post a reply
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Thursday, September 27, 2012
4 ideas for kids to document everyday life - Home Life Simplified
My kids are getting older now and wanting to use cameras and their ipods to document life through their own eyes. It is changing how we go to events, what gets captured on special days and how independent they feel when we trust them with technology and equipment.
We already have an adventure journal they are in charge of, but I went looking for ways they could document our life themselves and thought I?d share what I found. Most of these ideas can be adapted based on kids age and abilities.
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Family Fun and Adventure Journal
I have a post coming up on this in a couple of weeks detailing our journal in full. Basically after I wrote a post asking for fun ideas for our family and created the list of 101 ideas for fun and adventure I worked with my kids to create a journal where we could put together photos, details and any thoughts on our adventures. It it is nice to have something we can look back on together.
By giving the kids control of the camera on these outings we gain their perspective on the day and are also more fully able to participate since we are not hiding behind / busy with the camera.
Family Newspaper
I loved this post at Playful Learning on writing a family newspaper?as it ties in with my aim to encourage the kids in writing. You can go high tech like the article and work in publisher or another program or you can simply use paper and pen and photos while following the style of a newspaper. The post included a handout ?of two worksheets: ??On the first worksheet we recorded our newspaper observations. On the second worksheet we collected the basic information that all good reporters use to write a great story:? who, what, where, when, why and how! ?
This would be great over school holidays, summer or a year end wrap up for family and friends (in which case it could be an ongoing project).
Be a Photojournalist
Leaf journals have a great series going on with kids journal activities. One of the ideas is kids documenting ?a day in the life? for their own daily activities and routines. They don?t need to document every minute of the day, but it is great to have a record of their meals, clothes, friends, hobbies, favourite ways to spend time, etc
I could see this being a great long term project to capture your child at each age ? but done solely by them through photos.
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Scrapbooking
Often thought of as an adult pursuit, scrapbooking is a great activity for kids, especially those that love both craft and photography. Both my kids have received scrapbook kits from friends in the last 2 years and that is a quick way to start. Otherwise you can find a simple scrapbook or art journal and let them create freely with stamps, stickers, papers, craft punches and pens along with selecting which photos they want to have printed.
If you don?t already have many of these arts and crafts supplies this can be a great gift to pull together and invest in some grown up supplies.
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Have you tried any of these with your own kids? Do you think you will try one of these now??
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Find your simple,
Deb?
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Image credit ? photo used is by flickr user Mike Miley?
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Source: http://www.homelifesimplified.com.au/4-ideas-for-kids-to-document-everyday-life/
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Einstein's brain is now interactive iPad app
This digitized image made from a screen shot of a new iPad app, provided Sept. 24, 2012 by the National Museum of Health and Medicine Chicago, shows an image of brain tissue from renowned theoretical physicist Albert Einstein. The new application to be released Tuesday, Sept. 25 will allow users to see Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/Courtesy the National Museum of Health and Medicine Chicago)
This digitized image made from a screen shot of a new iPad app, provided Sept. 24, 2012 by the National Museum of Health and Medicine Chicago, shows an image of brain tissue from renowned theoretical physicist Albert Einstein. The new application to be released Tuesday, Sept. 25 will allow users to see Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/Courtesy the National Museum of Health and Medicine Chicago)
In this Monday, Sept. 24, 2012 photo, Dr. Phillip Epstein, left, and Steve Landers of the National Museum of Health and Medicine Chicago talk about the new iPad app being released Tuesday, Sept. 25 that allows users to see Albert Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/Carla K. Johnson)
This digitized image taken from a screen shot of a new iPad app, provided Sept. 24, 2012 by the National Museum of Health and Medicine Chicago, shows an image of a portion of the brainstem of renowned theoretical physicist Albert Einstein. The new application to be released Tuesday, Sept. 25 will allow users to see Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/The National Museum of Health and Medicine Chicago)
In this Monday, Sept. 24, 2012 photo, Dr. Phillip Epstein, left, and Steve Landers of the National Museum of Health and Medicine Chicago talk about the new iPad app being released Tuesday, Sept. 25 that allows users to see Albert Einstein's brain as if they were looking through a microscope. The application promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look. (AP Photo/Carla K. Johnson)
CHICAGO (AP) ? The brain that revolutionized physics now can be downloaded as an app for $9.99. But it won't help you win at Angry Birds.
While Albert Einstein's genius isn't included, an exclusive iPad application launched Tuesday promises to make detailed images of his brain more accessible to scientists than ever before. Teachers, students and anyone who's curious also can get a look.
A medical museum under development in Chicago obtained funding to scan and digitize nearly 350 fragile and priceless slides made from slices of Einstein's brain after his death in 1955. The application will allow researchers and novices to peer into the eccentric Nobel winner's brain as if they were looking through a microscope.
"I can't wait to find out what they'll discover," said Steve Landers, a consultant for the National Museum of Health and Medicine Chicago who designed the app. "I'd like to think Einstein would have been excited."
After Einstein died, a pathologist named Thomas Harvey performed an autopsy, removing the great man's brain in hopes that future researchers could discover the secrets behind his genius.
Harvey gave samples to researchers and collaborated on a 1999 study published in the Lancet. That study showed a region of Einstein's brain ? the parietal lobe ? was 15 percent wider than normal. The parietal lobe is important to the understanding of math, language and spatial relationships.
The new iPad app may allow researchers to dig even deeper by looking for brain regions where the neurons are more densely connected than normal, said Dr. Phillip Epstein, a Chicago-area neuroscientist and consultant for the museum.
But because the tissue was preserved before modern imaging technology, it may be difficult for scientists to figure out exactly where in Einstein's brain each slide originated. Although the new app organizes the slides into general brain regions, it doesn't map them with precision to an anatomical model.
"They didn't have MRI. We don't have a three-dimensional model of the brain of Einstein, so we don't know where the samples were taken from," said researcher Jacopo Annese of the Brain Observatory at the University of California, San Diego. What's more, the 1-inch-by-3-inch Einstein slides on the app represent only a fraction of the entire brain, Annese said.
Annese has preserved and digitized another famous brain, that of Henry Molaison, who died in 2008 after living for decades with profound amnesia. Known as "H.M." in scientific studies, Molaison participated during his life in research that revealed new insights on learning and memory.
A searchable website with images of more than 2,400 slides of Molaison's entire brain will be available to the public in December, Annese said.
"There will be another Einstein and we'll do it like H.M.," Annese predicted. For now, he said, it's exciting that the Einstein brain tissue has been preserved digitally before the slides deteriorate or become damaged. The app will spark interest in the field of brain research, just because it's Einstein, he said.
"It's a beautiful collection to have opened up to the public," Annese said.
Some may question whether Einstein would have wanted images of his remains sold to non-scientists for $9.99.
"There's been a lot of debate over what Einstein's intentions were," museum board member Jim Paglia said. "We know he didn't want a circus made of his remains. But he understood the value to research and science to study his brain, and we think we've addressed that in a respectful manner."
Paglia said the app could "inspire a whole new generation of neuroscientists."
Proceeds from sales will go to the U.S. Department of Defense's National Museum of Health and Medicine in Silver Spring, Md., and to the Chicago satellite museum, which is set to open in 2015 with interactive exhibits and the museum's digital collections.
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AP Medical Writer Carla K. Johnson can be reached at http://www.twitter.com/CarlaKJohnson .
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Wednesday, September 26, 2012
IBM Acquires Butterfly Software For Data Analysis And Advanced ...
IBM has acquired Butterfly Software, a privately held data analysis and migration software company headquartered in Maidenhead, England. Financial terms were not disclosed.
Butterfly?s main feature is its ability to migrate data center infrastructures. According to the company website, it focuses on lowering the cost and risk of maintaining legacy storage and backup & recovery environments. This allows companies to consolidate enterprise data and analyze it for strategic purposes.
IBM has staked its claim in the analytics market. This acquisition plays to that strategy.
The news follows IBM?s$1.3 billion acquisition last month of Kenexa, which helps companies cull vast amounts of data to make decisions and study trends.
IBM plans to continue its acquisition strategy for analytics companies. Its goal is to generate $16 billion from business analytics by 2015.
Another play here is for IBM to provide deeper capabilities it can offer in the storage market. Backup is a bear for companies and analysis will be increasingly important as companies store an increasing amount of data.
IBM, acronym for International Business Machines, is a multinational computer technology and consulting corporation. The company is one of the few information technology companies with a continuous history dating back to the 19th century. IBM manufactures and sells computer hardware and software, and offers infrastructure services, hosting services, and consulting services in areas ranging from mainframe computers to nanotechnology.
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Autographer wearable camera takes the whole taking pictures thing out of taking pictures
Sure, we've all got a camera on us at all times, thanks to the prevalence of smartphones and point-and-shoots, but these devices present an issue when it comes to that modern human desire to electronically capture everything that happens everywhere ever: having to actually take the pictures. That's why the unsettlingly giddily-named OMG Life is working to unleash the Autographer, a hands-free, wearable camera that promises to take "thousands of photographs a day" via its wearable lens. Just drape it on your person and it will uses its six on-board sensors (GPS, color, accelerometer, motion detector, magnetometer and thermometer) to determine the right moment to snap one of its unwieldy volume of images. Says the company,
For instance, Autographer might capture an image when the wearer speeds up as they run for the bus, moves from a warm pub to a snowy street or turns around to greet a friend.
Also, you know, stuff like your wedding and the birth of your child. The camera's got a five-megapixel sensor, OLED display, 8GB of on-board storage and built-in Bluetooth for sharing those pictures. The company's currently aiming for a November release, just in time for capturing every single moment of the holiday season. In the meantime, the press info is after the break.
Filed under: Cameras, Wearables
Autographer wearable camera takes the whole taking pictures thing out of taking pictures originally appeared on Engadget on Tue, 25 Sep 2012 05:33:00 EDT. Please see our terms for use of feeds.
PermalinkDP Review | Autographer | Email this | CommentsSource: http://www.engadget.com/2012/09/25/autographer-wearable-camera-takes-the-whole-taking-pictures-thin/
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